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BAHealth2 days ago

After three decades, scientists have solved the mystery of severe inflammatory bowel disease

Scientists from the United Kingdom and Denmark have resolved a significant part of the mystery surrounding severe forms of inflammatory bowel disease (IBD) after over 30 years of research. The study found that a specific genetic variant, HLA-DRB1*01:03, can trigger the production of antibodies that mistakenly attack interleukin 10 (IL-10), a key protein that normally reduces inflammation in the body. In individuals with this variant and IBD, the body may develop antibodies that neutralize IL-10, leading to stronger and longer-lasting intestinal inflammation. The study analyzed approximately 4,

Naučnici iz Ujedinjenog Kraljevstva i Danske nakon viÅ”e od 30 godina rada rijeÅ”ili su važan dio slagalice vezane za teÅ”ke oblike upalne bolesti crijeva (IBD), koja pogađa milione ljudi Å”irom svijeta.

Istraživanje je pokazalo da određena genetska varijanta HLA-DRB1*01:03 može potaknuti stvaranje antitijela koja pogreÅ”no napadaju interleukin 10 (IL-10), ključni protein koji u normalnim uslovima smanjuje upalne procese u organizmu.

Kod osoba s tom varijantom i IBD-om, organizam može razviti antitijela koja neutraliziraju IL-10, čime se gubi njegova zaŔtitna uloga i dolazi do jačih i dugotrajnijih upala crijeva.

U studiji je analizirano oko 4.900 pacijenata i približno 1.000 zdravih ispitanika. Neutralizirajuća antitijela pronađena su samo kod oboljelih, kod oko 3,5 posto njih, Å”to ukazuje na jasnu povezanost s boleŔću.

Stručnjaci ističu da ovo otkriće otvara mogućnost preciznijeg i ciljano usmjerenog liječenja za određenu grupu pacijenata, umjesto dosadaÅ”njih terapija koje uglavnom ublažavaju simptome.

Iako se radi o manjem procentu oboljelih, u globalnim razmjerama to i dalje predstavlja veliki broj ljudi, zbog čega se ovo otkriće smatra značajnim iskorakom u razumijevanju i liječenju IBD-a.

Read the full article at Dnevni avaz ā†’
Source document: Scientific Study on IBD and Genetic Variant HLA-DRB1*01:03

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Dnevni avazParty-alignedCenter2 days ago
After three decades, scientists have solved the mystery of severe inflammatory bowel disease

Scientists from the United Kingdom and Denmark have resolved a significant part of the mystery surrounding severe forms of inflammatory bowel disease (IBD) after over 30 years of research. The study found that a specific genetic variant, HLA-DRB1*01:03, can trigger the production of antibodies that mistakenly attack interleukin 10 (IL-10), a key protein that normally reduces inflammation in the body. In individuals with this variant and IBD, the body may develop antibodies that neutralize IL-10, leading to stronger and longer-lasting intestinal inflammation. The study analyzed approximately 4,

Bias read (Center): The article discusses a scientific discovery related to inflammatory bowel disease without any political framing, bias, or ideological emphasis. It presents findings objectively, focusing on the medical implications rather than any political or social controversy.

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  • study Scientific Study on IBD and Genetic Variant HLA-DRB1*01:03

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  • studyScientific Study on IBD and Genetic Variant HLA-DRB1*01:03