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Artificial intelligence has discovered dozens of new antibiotic candidates encoded within prions
Croatia🔬 Scienceyesterday

Artificial intelligence has discovered dozens of new antibiotic candidates encoded within prions

Scientists at the University of Pennsylvania used artificial intelligence to analyze peptides within prions and discovered over 1,000 potential antibiotic candidates. The study, published in 'Nature Microbiology', examined millions of short peptide fragments from thousands of prion proteins across various species. While prions are known for causing fatal neurodegenerative diseases, they are composed of amino acid chains called peptides, some of which exhibit antibacterial properties. The AI system identified 1,179 promising antibiotic-like peptides, with 75 tested against 11 bacterial strains, including antibiotic-resistant ones. At least 59 showed activity against pathogens, and 42 demonstrated strong efficacy at low concentrations.

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Artificial intelligence has discovered dozens of new antibiotic candidates encoded within prions

Scientists at the University of Pennsylvania used artificial intelligence to analyze peptides within prions and discovered over 1,000 potential antibiotic candidates. The study, published in 'Nature Microbiology', examined millions of short peptide fragments from thousands of prion proteins across various species. While prions are known for causing fatal neurodegenerative diseases, they are composed of amino acid chains called peptides, some of which exhibit antibacterial properties. The AI system identified 1,179 promising antibiotic-like peptides, with 75 tested against 11 bacterial strains, including antibiotic-resistant ones. At least 59 showed activity against pathogens, and 42 demonstrated strong efficacy at low concentrations.

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