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Like a molecular shrink ray, AI tool redesigns proteins without sacrificing function
United Kingdom🔬 Science7 hr. ago

Like a molecular shrink ray, AI tool redesigns proteins without sacrificing function

Researchers at Duke University School of Medicine have developed an AI tool named Raygun that can redesign proteins while maintaining their structure and function. Unlike traditional methods that require starting from scratch, Raygun uses protein language models trained on millions of natural protein sequences to modify existing proteins. This allows for creating shorter, longer, or highly modified versions of proteins with preserved functionality. The tool was tested through various experiments, including cell studies and receptor-binding assays, which demonstrated its effectiveness in maintaining structural integrity and functional sites. Published in Nature, this advancement opens new possibilities for customizing proteins for applications in medicine and biotechnology.

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Phys.org logoPhys.orgIndependentCenter7 hr. ago
Like a molecular shrink ray, AI tool redesigns proteins without sacrificing function

Researchers at Duke University School of Medicine have developed an AI tool named Raygun that can redesign proteins while maintaining their structure and function. Unlike traditional methods that require starting from scratch, Raygun uses protein language models trained on millions of natural protein sequences to modify existing proteins. This allows for creating shorter, longer, or highly modified versions of proteins with preserved functionality. The tool was tested through various experiments, including cell studies and receptor-binding assays, which demonstrated its effectiveness in maintaining structural integrity and functional sites. Published in Nature, this advancement opens new possibilities for customizing proteins for applications in medicine and biotechnology.

Bias read (Center): The article presents scientific research without political implications. It focuses on technological advancements in protein engineering and does not take a stance on political issues or ideologies.

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