United KingdomResearchers have developed a new technique called nanozyme proximity labeling (NPL) that allows mapping of nanoparticle movement inside living cells without requiring genetic engineering. This method uses iron oxide nanoparticles with peroxidase-like activity to label nearby proteins in real time, enabling detailed analysis of how different types of nanoparticles interact with cellular components. The study, published in the Proceedings of the National Academy of Sciences, showed that mitochondria-targeted nanoparticles interact more strongly with mitochondrial proteins and trafficking mediators, while non-targeted nanoparticles tend to be directed toward lysosomal degradation. This approach could improve the design of nanomedicines by offering insights into how surface modifications affect nanoparticle behavior within cells.
Procjena pristranosti (Sredina): The article presents scientific findings without overt ideological framing. It focuses on technical advancements in nanotechnology and biomedical research, which are generally considered apolitical topics. The language remains objective, emphasizing the novelty and potential applications of the NPL-
