Fourth-year vet students reveal clues to horse MEED and dog bone cancer

Fourth-year veterinary medicine students at Texas Tech University, Kayden Tanner and Marshall Mays, have made groundbreaking contributions to veterinary science by publishing research on two complex conditions affecting horses and dogs. Their studies, completed under the guidance of faculty members Thu Annelise Nguyen and Tomas Lugo, have resulted in publications in prestigious scientific journals. Tanner’s work focuses on a rare equine disorder known as multisystem eosinophilic epitheliotropic disease (MEED), while Mays’ research explores potential treatments for canine osteosarcoma, a type of bone cancer in dogs. Tanner’s study, titled “Genomics in Equine MEED: Whole-Genome Sequencing and Target Mutation Identification,” was published in the journal Animals and featured as a highlight. His research involved performing whole-genome sequencing on horses diagnosed with MEED, a condition characterized by severe inflammation and progressive deterioration. The disease typically leads to the euthanasia of affected horses within a year of diagnosis due to its rapid progression. Through his analysis, Tanner identified key genetic mutations associated with the condition, offering new insights into its underlying mechanisms. These findings could aid in developing targeted therapies and improving diagnostic methods for veterinarians treating similar cases. Mays’ research, “Evaluating the synergistic effects of cisplatin and tamoxifen in canine osteosarcoma cells,” was published in Frontiers in Veterinary Science. His work examined how combining the chemotherapy drug cisplatin with the hormone therapy tamoxifen might enhance treatment outcomes for dogs suffering from osteosarcoma. The study highlights the importance of interdisciplinary approaches in veterinary oncology, particularly through the lens of the One Health initiative, which recognizes the interconnectedness of human, animal, and environmental health. Mays’ findings suggest that such combinations could offer more effective treatment options for canine patients, potentially extending their quality of life and survival rates. Both students were mentored by Thu Annelise Nguyen, associate dean for research and a professor of toxicology, and Tomas Lugo, a postdoctoral fellow who played a pivotal role in guiding the students through their research. Lugo not only provided technical support and mentorship but also developed the computational models and experimental frameworks that enabled the successful completion of both projects. His efforts were recognized as the corresponding author on both papers, marking a notable achievement for the School of Veterinary Medicine, as no prior student had reached this level of academic recognition. Nguyen emphasized the significance of the students’ accomplishments, noting that they began with little to no prior experience in scientific research. The students demonstrated exceptional dedication, often arriving at campus before dawn and continuing their work during holidays. Their perseverance and willingness to engage deeply with their studies exemplify the qualities of future veterinary professionals. Nguyen expressed pride in the mentorship provided by Lugo, who helped transform the students from passive observers into active participants in cutting-edge research. Lugo reflected on the experience, stating that mentoring the students allowed him to refine his skills and gain confidence in his ability to lead independent research projects. He noted that witnessing the students’ growth mirrored his own journey, reinforcing his decision to pursue a career in academia. His ultimate goal is to establish his own research laboratory, providing future students with the same opportunities that he and Nguyen offered to Tanner and Mays. The publications resulting from this collaboration underscore the value of early exposure to advanced research methodologies in veterinary education. Both Tanner and Mays are now better positioned to secure internships that will prepare them for careers as veterinary surgeons. Their success also serves as a testament to the supportive environment fostered by Texas Tech University’s School of Veterinary Medicine, where innovative research and dedicated mentorship converge to produce impactful scientific contributions.