United KingdomResearchers at Karolinska Institutet and SciLifeLab have developed a new technique called spectral biophysical cytometry (SBC) to assess the condition of immune cells in blood samples. This method uses fluorescent nanosensors combined with flow cytometry to measure multiple physical properties of individual cells simultaneously. The technique was tested on 38 patients with atherosclerosis and 26 healthy controls, revealing distinct physical differences in immune cells between groups. These findings suggest that physical characteristics of cells may reflect health status and play a role in disease progression. The study, published in Nature Nanotechnology, is a proof-of-concept and aims to explore broader applications in other diseases.
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